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[(1R)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]amino]butyl]boronic acid

179324-69-7 C19H25BN4O4

About [(1R)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]amino]butyl]boronic acid

[(1R)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]amino]butyl]boronic acid (CAS 179324-69-7) is a chemical compound with the molecular formula C19H25BN4O4 and a molecular weight of 384.2 g/mol. It has an InChIKey of GXJABQQUPOEUTA-RDJZCZTQSA-N.

Properties

[(1R)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]amino]butyl]boronic acid molecular structure
CAS Number
179324-69-7
Formula
C19H25BN4O4
Molecular Weight
384.2 g/mol
IUPAC Name
[(1R)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]amino]butyl]boronic acid
InChI Key
GXJABQQUPOEUTA-RDJZCZTQSA-N

Also Known As

[(1R)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]amino]butyl]boronic acid is also known as Bortezomib, Velcade, Bortezomib accord, bortezomibum, Bortexomib, BORUZU, among other names.

Bortezomib Velcade PS-341 LDP-341 NSC-681239 DTXSID3040980 LDP 341 Bortezomib accord 69G8BD63PP N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE

Description

Bortezomib is L-Phenylalaninamide substituted at the amide nitrogen by a 1-(dihydroxyboranyl)-3-methylbutyl group and at Nalpha by a pyrazin-2-ylcarbonyl group. It is a dipeptidyl boronic acid that reversibly inhibits the 26S proteasome. It has a role as an antineoplastic agent, an antiprotozoal drug, a protease inhibitor and a proteasome inhibitor. It is an amino acid amide, a member of pyrazines and a L-phenylalanine derivative. It is functionally related to a boronic acid.

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