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2-[5-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine

446859-33-2 C17H13N5

About 2-[5-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine

2-[5-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine (CAS 446859-33-2) is a member of the pyrazoles class of chemical compounds with the molecular formula C17H13N5 and a molecular weight of 287.32 g/mol. It has an InChIKey of LBPKYPYHDKKRFS-UHFFFAOYSA-N.

Properties

2-[5-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine molecular structure
CAS Number
446859-33-2
Formula
C17H13N5
Molecular Weight
287.32 g/mol
IUPAC Name
2-[5-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine
InChI Key
LBPKYPYHDKKRFS-UHFFFAOYSA-N

Also Known As

2-[5-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine is also known as RepSox, ALK5 Inhibitor II, ALK5 Inhibitor, RepSox (GMP), Alk 5 Inhibitor II, 1vjy, among other names.

RepSox SJN 2511 E-616452 SJN-2511 JT8ZW3H2ST E 616452 E616452 RefChem:879262 663-924-9 2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine

Description

RepSox is a member of the class of pyrazoles that is 1H-pyrazole substituted by 6-methylpyridin-2-yl and 1,5-naphthyridin-2-yl groups at positions 3 and 4, respectively. It is a potent and selective inhibitor of TGF-beta R1 kinase (IC50 = 4 nM) and ALK5 autophosphorylation and binding (IC50 = 23 nM). It has a role as an antineoplastic agent, a bone density conservation agent, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor and a TGFbeta receptor antagonist. It is a member of pyrazoles, a member of pyridines and a 1,5-naphthyridine derivative.

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