(E)-3-phenyl-N-[2,2,2-tric… (CAS 405060-95-9)

About (E)-3-phenyl-N-[2,2,2-trichloro-1-(quinolin-8-ylcarbamothioylamino)ethyl]prop-2-enamide

(E)-3-phenyl-N-[2,2,2-trichloro-1-(quinolin-8-ylcarbamothioylamino)ethyl]prop-2-enamide (CAS 405060-95-9) is a member of the quinolines class of chemical compounds with the molecular formula C21H17Cl3N4OS and a molecular weight of 479.8 g/mol. It has an InChIKey of LCOIAYJMPKXARU-VAWYXSNFSA-N.

Properties

(E)-3-phenyl-N-[2,2,2-trichloro-1-(quinolin-8-ylcarbamothioylamino)ethyl]prop-2-enamide molecular structure

CAS Number: 405060-95-9
Formula: C21H17Cl3N4OS
Molecular Weight: 479.8 g/mol
IUPAC Name: (E)-3-phenyl-N-[2,2,2-trichloro-1-(quinolin-8-ylcarbamothioylamino)ethyl]prop-2-enamide
InChI Key: LCOIAYJMPKXARU-VAWYXSNFSA-N

Also Known As

(E)-3-phenyl-N-[2,2,2-trichloro-1-(quinolin-8-ylcarbamothioylamino)ethyl]prop-2-enamide is also known as salubrinal, Salubrinal?, eIF-2? Inhibitor, LCOIAYJMPKXARU-VAWYXSNFSA-N, among other names.

salubrinal J8PSF5Z8KJ (2E)-3-phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide CHEBI:131923 DTXSID70420852 (2E)-3-PHENYL-N-(2,2,2-TRICHLORO-1-(((8-QUINOLINYLAMINO)THIOXOMETHYL)AMINO)ETHYL)-2-PROPENAMIDE RefChem:884483 DTXCID50832434 MFCD00548612 (E)-N-(2,2,2-Trichloro-1-(3-(quinolin-8-yl)thioureido)ethyl)cinnamamide

(2E)-3-phenyl-N-(2,2,2-trichloro-1-{[(quinolin-8-yl)carbamothioyl]amino}ethyl)prop-2-enamide N-(2,2,2-trichloro-1-(3-(quinolin-8-yl)thioureido)ethyl)cinnamamide C21H17Cl3N4OS (E)-3-phenyl-N-[2,2,2-trichloro-1-(8-quinolylcarbamothioylamino)ethyl]prop-2-enamide Salubrinal? eIF-2? Inhibitor UNII-J8PSF5Z8KJ CHEMBL180127 orb1304594 SCHEMBL6477826 SCHEMBL17360638 CHEBI:91873 LCOIAYJMPKXARU-VAWYXSNFSA-N HMS3413G22 HMS3677G22 EX-A2153 EBC-50076 HB0573 s2923 STL253110 AKOS000525027 AKOS016042385 CCG-269541 3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide NCGC00159554-01 NCGC00159554-09 AC-33176 DA-67387 NS-05839 ST078198 SW102000-2 T3045 C75050 M03998 Q7406268 BRD-A45107007-001-02-6 BRD-A45107007-001-03-4 BRD-A45107007-001-05-9 BRD-A77299732-001-01-6 F0095-1218

Description

Salubrinal is a member of the class of quinolines that is a mixed aminal resulting from the formal condensation oftrichloroacetaldehyde with the amide nitrogen of trans-cinnamamide and the primary amino group of 1-quinolin-8-ylthiourea. It is a selective inhibitor of cellular complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit alpha (eIF2alpha). It is a secondary carboxamide, a member of quinolines, an aminal, an organochlorine compound and a member of thioureas. It is functionally related to a trichloroacetaldehyde and a trans-cinnamamide.

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