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N-[3-[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl]propane-1-sulfonamide

918504-65-1 C23H18ClF2N3O3S

About N-[3-[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl]propane-1-sulfonamide

N-[3-[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl]propane-1-sulfonamide (CAS 918504-65-1) is a chemical compound with the molecular formula C23H18ClF2N3O3S and a molecular weight of 489.9 g/mol. It has an InChIKey of GPXBXXGIAQBQNI-UHFFFAOYSA-N.

Properties

N-[3-[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl]propane-1-sulfonamide molecular structure
CAS Number
918504-65-1
Formula
C23H18ClF2N3O3S
Molecular Weight
489.9 g/mol
IUPAC Name
N-[3-[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl]propane-1-sulfonamide
InChI Key
GPXBXXGIAQBQNI-UHFFFAOYSA-N

Also Known As

N-[3-[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl]propane-1-sulfonamide is also known as Vemurafenib, Zelboraf, vemurafenibum, Ro 51-85426, BRAF(V600E) Kinase Inhibitor RO5185426, BRAF (V600E) kinase inhibitor RO5185426, among other names.

Vemurafenib Zelboraf PLX-4032 PLX 4032 RG7204 RG 7204 RO 5185426 vemurafenibum N-(3-{[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl}-2,4-difluorophenyl)propane-1-sulfonamide RG-7204

Description

Vemurafenib is a pyrrolopyridine that is 1H-pyrrolo[2,3-b]pyridine which is substituted at position 5 by a p-chlorophenyl group and at positions 3 by a 3-amino-2,6-difluorobenzoyl group, the amino group of which has undergone formal condensation with propane-1-sulfonic acid to give the corresponding sulfonamide. An inhibitor of BRAF and other kinases. It has a role as an antineoplastic agent and a B-Raf inhibitor. It is a sulfonamide, a difluorobenzene, a pyrrolopyridine, an aromatic ketone and a member of monochlorobenzenes.

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