methyl (4S)-5-[[(2S)-1-[[(… (CAS 210344-95-9)

About methyl (4S)-5-[[(2S)-1-[[(3S)-5-fluoro-1-methoxy-1,4-dioxopentan-3-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-[[(2S)-4-methoxy-4-oxo-2-(phenylmethoxycarbonylamino)butanoyl]amino]-5-oxopentanoate

methyl (4S)-5-[[(2S)-1-[[(3S)-5-fluoro-1-methoxy-1,4-dioxopentan-3-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-[[(2S)-4-methoxy-4-oxo-2-(phenylmethoxycarbonylamino)butanoyl]amino]-5-oxopentanoate (CAS 210344-95-9) is a chemical compound with the molecular formula C30H41FN4O12 and a molecular weight of 668.7 g/mol. It has an InChIKey of GBJVAVGBSGRRKN-JYEBCORGSA-N.

Properties

CAS Number: 210344-95-9
Formula: C30H41FN4O12
Molecular Weight: 668.7 g/mol
IUPAC Name: methyl (4S)-5-[[(2S)-1-[[(3S)-5-fluoro-1-methoxy-1,4-dioxopentan-3-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-[[(2S)-4-methoxy-4-oxo-2-(phenylmethoxycarbonylamino)butanoyl]amino]-5-oxopentanoate
InChI Key: GBJVAVGBSGRRKN-JYEBCORGSA-N

Also Known As

methyl (4S)-5-[[(2S)-1-[[(3S)-5-fluoro-1-methoxy-1,4-dioxopentan-3-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-[[(2S)-4-methoxy-4-oxo-2-(phenylmethoxycarbonylamino)butanoyl]amino]-5-oxopentanoate is also known as Z-DEVD-FMK, Z-Asp-Glu-Val-Asp-fluoromethyl ketone, Caspase-3 Inhibitor, Z-D(OMe)E(Ome)VD(OMe)-FMK, Z-DEVD-fluoromethylketone, Z-DEVD-fluoromethyl ketone, among other names.

Z-DEVD-FMK benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethylketone CHEBI:138013 N-benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethyl ketone RefChem:934475 benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone Z-Asp-Glu-Val-Asp-fluoromethyl ketone Caspase-3 Inhibitor C30H41FN4O12 Z-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OMe)-fluoromethylketone

L-Valinamide, N-[(phenylmethoxy)carbonyl]-L-alpha-aspartyl-L-alpha-glutamyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-, 1,2-dimethyl ester Z-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-Fluoromethylketone Z-Asp(O-Me)-Glu(O-Me)-Val-Asp(O-Me) fluoromethyl ketone Z-D(OMe)E(Ome)VD(OMe)-FMK methyl (5S,8S,11S,14S)-14-(2-fluoroacetyl)-11-isopropyl-5-(2-methoxy-2-oxoethyl)-8-(3-methoxy-3-oxopropyl)-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oate MFCD23380217 Z-DEVD-fluoromethylketone Z-DEVD-fluoromethyl ketone orb1301196 specific inhibitor of caspase-3 CHEMBL3963349 SCHEMBL18328791 DTXSID00879990 BDBM228619 GLXC-08057 EX-A1761 HB1282 US9345789, Z-DEVD-FMK AKOS024456968 CS-3454 AC-31504 BP-23680 BS-16593 DA-68816 FA111066 HY-12466 T6005 D71045 Z-Asp(OCH3)-Glu(OCH3)-Val-Asp(OCH3)-CH2F Q60998625 benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethyl ketone N-benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethyl-ketone Z-Asp(O-Me)-Glu(O-Me)-Val-Asp(O-Me) fluoromethyl ketone, >=90% (HPLC) (5S,8S,11S,14S)-methyl 14-(2-fluoroacetyl)-11-isopropyl-5-(2-methoxy-2-oxoethyl)-8-(3-methoxy-3-oxopropyl)-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oate L-Valinamide, N-[(phenylmethoxy)carbonyl]-L-|A-aspartyl-L-|A-glutamyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-, 1,2-dimethyl ester methyl (4S)-4-[[(2S)-2-(benzyloxycarbonylamino)-4-methoxy-4-oxo-butanoyl]amino]-5-[[(1S)-1-[[(1S)-3-fluoro-1-(2-methoxy-2-oxo-ethyl)-2-oxo-propyl]carbamoyl]-2-methyl-propyl]amino]-5-oxo-pentanoate methyl (4S)-5-{[(2S)-1-amino-3-methyl-1-oxobutan-2-yl]amino}-4-{[(2S)-2-{[(benzyloxy)carbonyl]amino}-4-methoxy-4-oxobutanoyl]amino}-5-oxopentanoate methyl (5S,8S,11S,14S)-14-(fluoroacetyl)-11-isopropyl-5-(2-methoxy-2-oxoethyl)-8-(3-methoxy-3-oxopropyl)-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oate N-[(phenylmethoxy)carbonyl]-L-alpha-aspartyl-L-alpha-glutamyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-L-valinamide, 1,2-dimethyl ester

Description

Z-DEVD-FMK is a tetrapeptide consisting of Fmoc-L-aspartic acid 4-methyl ester, methyl L-alpha-glutamic acid 5-methyl ester, L-valine and the fluoromethyl ketone derived from the 1-carboxy group of L-aspartic acid 4-methyl ester coupled in sequence. It is a specific, irreversible caspase-3 inhibitor that also shows potent inhibition of caspase-6, caspase-7, caspase-8, and caspase-10. It has a role as an EC 3.4.22.56 (caspase-3) inhibitor, a neuroprotective agent and an apoptosis inhibitor.

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methoxymethane CAS 115-10-6 methyl (15S,16R,18R)-16-hydroxy-15-methyl-3-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.115,18.02,6.07,27.08,13.019,26.020,25]octacosa-1,6,8,10,12,20,22,24,26-nonaene-16-carboxylate CAS 99533-80-9 methyl (1R,2S,9R,10R,11S,14R,15S,17R)-2,15-dimethyl-5,5'-dioxospiro[18-oxapentacyclo[8.8.0.01,17.02,7.011,15]octadec-6-ene-14,2'-oxolane]-9-carboxylate CAS 107724-20-9 methyl (2E,4Z)-deca-2,4-dienoate CAS 4493-42-9 methyl (2S)-8',10-dihydroxy-5',7'-dimethoxy-4',9,9'-trioxospiro[3,4-dihydropyrano[4,3-g]chromene-2,2'-3H-benzo[f][1]benzofuran]-7-carboxylate CAS 27267-70-5 methyl (9Z,12Z)-octadeca-9,12-dienoate CAS 112-63-0 methyl (Z)-octadec-9-enoate CAS 112-62-9 methyl 4-hydroxybenzoate CAS 99-76-3 methyl benzoate CAS 93-58-3 Methyl Ethyl Ketone CAS 78-93-3

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methyl (4S)-5-[[(2S)-1-[[(3S)-5-fluoro-1-methoxy-1,4-dioxopentan-3-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-[[(2S)-4-methoxy-4-oxo-2-(phenylmethoxycarbonylamino)butanoyl]amino]-5-oxopentanoate